Northern ICU teaching program

2020

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19

B Tomazini, I Maia, A Cavalcanti, et al for the CoDEX Randomised Clinical Trial JAMA, 2020, online Sept 2020

High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation

G Hernandez Martinez, M-L Rodriguez, M-C Vaquero, et al New Eng J Med, 2020, 383:1009-1017

Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest

B Grunau, N Kime, B Lerous, et al JAMA, 2020, 324(11):1058-1067

Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury

S Rowell, E Meier, B McKnight, et al JAMA, 2020, 324(10):961-974

Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery The FACTOR Randomized Clinical Trial

A Turan, H Essäer, W Saasouh, et al for the FACTOR Study Group JAMA, 2020, 324(4):350-358

Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock The ACTS Randomized Clinical Trial

A Moskowitz, D Huang, P Houe et al for the ACTS Clinical Trial Investigators JAMA, 2020, 324(7):642-650

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

The RECOVERY Collaborative Group New Eng J Med, 2020, Online July 2020

Timing of Initiation of Renal Replacement Therapy in Acute Kidney Injury

The STARRT-AKI Investigators for the CCCTG, ANZICS-CTG, UKCCRG, CNTN, ICCTG New Eng J Med, 2020, Online July

Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality

Fosbel, J Butt, L Ostergaard, et al JAMA, 2020, 324(2):168-177

Remdesivir for the Treatment of Covid-19 — Preliminary Report

J Beigel, K Tomashek, L Dodd, A Mehta, for the ACTT-1 Study Group Members New Eng J Med, 2020, May 20

Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis

B Ferreyro, F Angriman, L Munshi, et al. JAMA, 2020, online May

Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients

H Olsen, H Nedergaard,T Strom, et al New Eng J Med, 2020, online 1st Feb 2020

Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery

E Futire, M Garot, T Godet, for the FLASH Trial Group JAMA, 2020, 32(3):225-236

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

T Fuji, N Luethi, P Young et al for the VITAMINS Trials Investigators JAMA, 2020, Online first 17th Jan

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

The PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group JAMA, 2020, Online first 17th Jan

2019

Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery - The FIBRES Randomized Clinical Trial

J Callum, M Farkouh, D Scales, et al for the FIBRES Research Group JAMA, 2019, Online October 2019

Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure

ArnaudW. Thille, Grégoire Muller, Arnaud Gacouin et al for the HIGH-WEAN Study Group and the REVA Research Network JAMA, 2019, 322(15):1465-1475

Frailty in very old critically ill patients in Australia and New Zealand: a population based cohort study

Jai N Darvall, Rinaldo Bellomo, Eldho Paul, et al MJA, 2019, 211 (7): 318-323

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group New Eng J Med, 2019, Online first

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial

The CRASH-3 Trial Collaborators The Lancet, 2019, Online first October

Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

J.-B. Lascarrou, H. Merdji, A. Le Gouge, et al for the CRICS-TRIGGERSEP Grou New Eng J Med, 2019, Online first Oct 2019

Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation

C Subira, G Hernandez, A Vazquez, et al JAMA, 2019, 321(22):2175-2182

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network New Eng J Med, 2019, online first May 2019

Early Sedation with Dexmedetomidine in Critically Ill Patients

Y. Shehabi, B.D. Howe, R. Bellomo, et al New Eng J Med, 2019, online May 2019

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

H Ma, B Campbell, M Parsons, for the EXTEND Investigators New Eng J Med, 2019, 380:1795-1803

Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Jorrit S. Lemkes, Gladys N. Janssens, Nina W. van der Hoeven, et al New Eng J Med, 2019, March 2019

Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis

Y Arabi, F Al-Hameed, K Burns, et al for the Saudi Critical Care Trials Group New Eng J Med, 2019, online first Feb 2019

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

J Casey, D Janz, D Russell, et al for the PreVent Investigators and the Pragmatic Critical Care Research Group New Eng J Med, 2019, online first Feb 2019

Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery

B Subramaniam, P Shankar, S Shaefi, etal JAMA, 2019, 321(7):686-696

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock

Hernandez G, Ospina-Tascon G, Damiani L, et al for the ANDROMEDA-SHOCK Investigators and the Latin America Intensive Care Network (LIVEN) JAMA, 2019, online Feb 2019

2016

Vasopressin versus norepinephrine infusion in patients with septic shock

Russell J, Walley K, Singer J, et al for the VASST Investigators NEJM, 2008, 358 (9):877-887

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit

S Gaudry, D Hajage, F Shortgen, et al for the AKIKI Study Group New Engl J Med, 2016, 375:122-133

Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury

A Zarboci, J Vellum, C Schmidt, et al JAMA, 2016, 315(20):2190-2199

Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery -A Randomized Clinical Trial

S Jaber, T Lescot, E Futier, et al for the NIVAS Study Group JAMA, 2016, online first 15th Mar

Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium - A Randomized Clinical Trial

M Reade, G Eastwood, R Bellow, et al, for the DahLIA Investigators and the ANZICS CTG JAMA, 2016, online 15th Mar 2016

Stopping vs. Continuing Aspirin before Coronary Artery Surgery

P Myles, J Smith, A Forbes, et al for the ATACAS Investigators of the ANZCA Clinical Trials Networks NEJM, 2016, 374;728-737

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

M Singer, C Deutschland, C Warren Seymour, M Shankar-Hari, D Annans, M Bauer, R Bellomo, G Bernard, J-D Chiche, C Coopersmith, R Hotchkiss, M Levy, J Marshall, G Martin, S Opal, G Rubenfeld, T vdPoll, J-L Vincent, D Angus. JAMA, 2016, 315(8):801-810

2015

A Multicenter Randomized Trial of Continuous versus Intermittent B-Lactam Infusion in Severe Sepsis

J Delahunty, J Roberts, J Davis, et al for the BLING II Investigators for the ANZICS Clinical Trials Group Am J Resp Crit Care Med, 2015, 192 (11); 1298-1305

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury

P Andrews, L Sinclair, A Rodriguez, et al for the Eurotherm3235 Trial Collaborators New Eng J Med, 2015, online 7th October

Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit - The SPLIT Randomized Clinical Trial

P Young, M Bailey, R Beasley, et al for the SPLIT Investigators and the ANZICS CTG JAMA, 2015, online first Oct 7,2015

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection

P Young, M Saxena, R Bellomo, et al for the HEAT Investigators and ANZICS CTG New Eng J Med, 2015, online first 5th Oct

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults

Y Arabi, A Aldawood, S Haddad, et al for the PermiT Trial Group NEJM, 2015, online first May 2015

Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection

R Sawyer, J Claridge, A Nathens, et al NEJM, 2015, 372:1996-2005

High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure

J-P Frat, A Thille, A Mercat, et al for the FLORALI Study Group and the REVA Network NEJM, 2015, online first May 2015

The Timing of Discharge from ICU and Subsequent Mortality: A Prospective Multi-center Study

John D Santamaria , Graeme J Duke , David V Pilcher , D James Cooper , John Moran , Rinaldo Bellomo , and for the Discharge and Readmission Evaluation (DARE) study Am J Resp Crit Care MEd, 2015, 191(9);1033-1039

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

Kirsi-Maija Kaukonen, Michael Bailey, David Pilcher, D. Jamie Cooper, Rinaldo Bellomo NEJM, 2015, Online first 17th Mar

Age of Transfused Blood in Critically Ill Adults

Jacques Lacroix, Paul C. Hébert, Dean A. Fergusson, et al, for the ABLE Investigators and the Canadian Critical Care Trials Group NEJM, 2015, online first Mar 17

Trial of Early, Goal-Directed Resuscitation for Septic Shock

Paul R. Mouncey, Tiffany M. Osborn, G. Sarah Power, et al for the ProMISe Trial Investigators NEJM, 2015, Online first 17 Mar

2014

Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock

the TRISS Trial Group and the Scandinavian Critical Care Trials Group NEJM, 2014, Online first October 1 2014

Trial of the Route of Early Nutritional Support in Critically Ill Adults

the CALORIES Trial Investigators NEJM, 2014 , Online first October 1 2014

Goal-Directed Resuscitation for Patients with Early Septic Shock

The ARISE Investigators and the ANZICS Clinical Trials Group NEJM, 2014, Online first October 1 2014

Hemicraniectomy in Older Patients with Extensive Middle-Cerebral-Artery Stroke

the Destiny II Investigators NEJM, 2014, 370:1091-1100

A Randomized Trial of Protocol-Based Care for Early Septic Shock

The ProCESS Investigators NEJM, 2014, online first 18th Mar 2014

High versus Low Blood-Pressure Target in Patients with Septic Shock

the SEPSISPAM Investigators NEJM, 2014, online first 18th Mar

Albumin Replacement in Patients with Severe Sepsis or Septic Shock

the ALBIOS Study Investigators NEJM, 2014, online first 18th Mar 2014